Contraindications of Some Cancer Chemotherapy By FACT
RethinkingCancer ParmarMay 7, 20200 comments

- NITROGEN MUSTARD (Mustargen)
Bone marrow depression occurs approximately 7 – 10 days after administration.
Nausea and vomiting. - TRIETHYLENE MELAMINE (TEM)
Bone marrow depression
Nausea and vomiting - THIO-TEPA
Same as nitrogen mustard. - BUSULFAN (Myleran)
Bone marrow depression
Nausea and vomiting
Hyperpigmentation with Addison-like syndrome.
Gynecomastia
Amenorrhea (cessation of the menses)
Pulmonary fibrosis - CH LORAMBUC IL (Leukeran)
Bone marrow depression
Nausea and vomiting - MELPHALAN (Alkeran)
Bone marrow depression
Nausea and vomiting - CYCLOPHOSPHAMIDE (Cytoxan)
Bone marrow depression
Nausea and vomiting
Alopecia (loss of hair)
Hemorrhagic cystitis – starts as increased
frequency and dysuria; can be very severe - VINBLASTINE (Velban)
Bone marrow depression
Nausea and vomiting
Neuromuscular toxicity - VINCRISTINE (Oncovin)
Severe constipation
Neuromuscular toxicity
Impaired extra-ocular movements
Cerebe llar signs-positive Romberg
Alopecia - 5 – FU (Fluorouracil) – inhibits thymidylate synthetase; pyrimidine antagonists
Bone marrow depression
Nausea and vomiting
Oral ulcerations
Bloody diarrhea
Treat for minimum of 8 weeks – if no response, discontinue; if patient responds, continue weekly 5-FU until relapse - ADRIAMYCIN
Bone marrow depression
Cardiac toxicity-premature ventricular contractions and congestive heart failure
Mucositis
Alopecia (hair loss) - 6 – MERCAPTOPURINE (Purinethol)
Bone marrow depression
Abdominal pain at onset of therapy
Hepatoxicity
Nausea and vomiting - CYTOSINE ARABINOSIDE (Cytosar) inhibits DNA
Severe bone marrow suppresion
Nausea and vomiting - ACTINOMYCIN-D (Cosmagen)
Bone marrow depression – may cause thrombocytopenia (reduction of platelets) before leukopenia
Nausea and vomiting
Skin eruptions
Oral ulcerations
Renal and hepatic toxicity - MITHRAMYCIN
Bone marrow depression
Nausea and vomiting
Hypocalcemia
Coagulopothies - DAUNOMYCIN (Rubidomycin) (Daunorubicin)
This drug is very toxic and often causes
marrow aplasia. - AMETHOPTERIN (Methotrexate) folic acid inhibitor
Bone marrow depression
Oral ulcerations
Nausea and vomiting
Diarrhea
Acne
Cirrhosis
Pneumonitis (Methotrexate lung)
Contraindicated in impaired renal function